“A deafening silence” is how Sarah Hawkes, Director of the Centre for Gender and Global Health at University College London (UCL), UK, recalls the reaction to a 2013 Lancet Viewpoint on gender and global health that she wrote with her husband Kent Buse. Its inclusive gender-based approach “was deemed politically unacceptable at the time, as most gender-based discussions in global health had hitherto focused on maternal health, in the context of sexual health and HIV”, she says. The agenda has now changed and a new Lancet Series examines gender equality, norms, and health. “I am thrilled The Lancet…is devoting a Series to highlighting the role that gender plays in influencing everyone’s health outcomes”, says Hawkes, who is a Series author. “As we work to ensure that the findings and recommendations of the Series are acted upon, I would hope to see an inclusive global response that brings a wider variety of voices, and genders, on board to ensure that gender is both understood and acted upon for health equity.”